Agitator Design Principals: Pharmaceutical and Biotechnology Applications

In Agitator Design Principals: Pharmaceutical and Biotechnology Applications, you'll learn ...

• Be able to choose the right impellers for the job
• Understand how power and pumping are calculated
• Understand the basics of gas dispersion
• Understand the basics of heat transfer

Overview

Preview a portion of this course before purchasing it.

Credit: 8 PDH

Length: 125 pages

This course presents a rather intense introduction to the major principles of agitator process design, as applied to liquid and gas-liquid systems as commonly found in the Bioprocessing and Pharmaceutical industries. A brief introduction is given to the basics of agitation theory as applicable, but the emphasis is on practical application of theory, rather than as an academic treatise. Specific guidelines are given for major industry applications, and sanitary aspects are covered as well. Several chapters are devoted entirely to aerobic fermentation design and scale-up, as this is an area which has been most neglected in courses of this kind.

This course is helpful for people who must specify, operate, purchase or optimize fluid agitation equipment used for Bioprocessing and Pharmaceutical applications. Such applications include, for example, simple tanks containing CIP solutions, broth and slurry tanks, compounding tanks and fermenters/bioreactors. The application technology ranges from simple to complex, and the construction methods range from standard to highly sanitary. A basic Introduction to general agitator design principles is given, but the focus is specifically on applications found in the Pharmaceutical Bioprocessing Industries.

Having a working knowledge of the terminology and technology used by agitator designers enables the attendee to assume a more active role in the purchase and operation of such equipment, instead of leaving everything in the hands of the vendors. The result can be a lower price paid by specifying clearly what is needed, while avoiding undersized equipment that can cause lost productivity. In the case of fermenters, proper information can even be essential to assure the right product is capable of being made, and that energy costs are minimized. Senior management can see how the agitator design can impact overall production and profit.

Learning Objectives

Upon completion of this course, participants will be able to:

• Select appropriate impellers for a given application.
• Calculate agitator power and pumping requirements.
• Explain the basic principles of gas dispersion.
• Describe the basic principles of heat transfer in agitated systems.
• Identify sanitary-design options for agitator systems.
• Compare the merits of common seal configurations.
• Apply bioprocessing sizing guidelines.
• Explain the capabilities and limitations of process scale-up.
• Identify the data required to design aerobic fermenters.
• Design a pilot fermentation protocol that provides the required design data.
• Explain how fermenters are scaled up.
• Identify methods for minimizing power consumption in fermenters.
• Compare the merits of common impeller types.
• Describe the unique design issues associated with cell-culture bioreactors.
• Analyze a fermenter as a dynamic system.
• Explain how CFD can aid system analysis.

Certificate of Completion

You will be able to immediately print a certificate of completion after passing a multiple-choice quiz consisting of 52 questions. PDH credits are not awarded until the course is completed and quiz is passed.